There are 148 car park spaces that operates 24/7. Parking is paid at $11 per day. There are several stree parking options within the vicinity of the Powerhouse . New Farm Park offers more than 200 free car parking spaces. New Farm Park gates open Mon–Fri 8.30am–11pm.

The 195 and 196 bus services stop at the end of Brunswick Street (near Oxlade Drive), on the East side of New Farm Park. The 199 bus stops at Merthyr Road and Hawthorne Street. Both stops are approximately 200 metres from Brisbane Powerhouse. The New Farm Ferry Terminal is located approximately 200 metres from Brisbane Powerhouse, with city cat services every 30 minutes until midnight.

Brisbane Powerhouse is conveniently located on the Newstead-New Farm Bikeway, which connects to the city centre via the New Farm Riverwalk. There are secure bike racks outside of the Stores and Turbine buildings so you can ride to the door.